Big Ten opponents meet when the No. 1 Ohio State Buckeyes (5-0) and the No. 17 Illinois Fighting Illini (5-1) square off on Saturday, October 11, 2025 at Memorial Stadium (Champaign, IL).

Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.

Ohio State vs. Illinois Matchup Info

Game date: Saturday, October 11, 2025
Game time: 12 p.m. ET
Location: Champaign, Illinois
Venue: Memorial Stadium (Champaign, IL)
TV channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Stop missing games and start streaming college football right now on Fubo.

Ohio State vs. Illinois Odds and Prediction

Spread favorite: Buckeyes (-14.5)
Moneyline: Buckeyes (-645), Fighting Illini (+468)
Total: 50.5 points
Pick ATS: Illinois (+14.5)
Pick OU: Under (50.5)
Prediction: Illinois 27, Ohio State 22

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.

Ohio State vs. Illinois Betting Records and Insights

Ohio State has put together a 4-1-0 record against the spread this season.
Illinois has won five games against the spread this year, failing to cover once.
The Buckeyes have covered the spread twice this season (2-1 ATS) when playing as at least 14.5-point favorites.
So far this season, two Ohio State games have gone over the point total.
So far this season, four of Illinois' six games with a set number have gone over the point total.

2 Pros and a Cup of Joe