Cleveland Browns quarterback Shedeur Sanders has a tough matchup in Week 16 (Sunday at 1 p.m. ET), playing the Buffalo Bills. The Bills are conceding the second-fewest passing yards in the NFL, 169.5 per game.
Sanders has thrown for 946 yards (189.2 per game) this season while completing 52.2% of his passes, with five TD passes and six picks. On 10 carries, Sanders has run for 74 yards, tallying one TD and averaging 14.8 rushing yards per game.
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Sanders vs. the Bills
- Sanders vs the Bills (since 2021): No games
- Not a single opposing quarterback has registered 300 or more passing yards in an outing against Buffalo this season.
- The Bills have allowed one or more passing TDs to nine opposing quarterbacks this season.
- Buffalo has allowed five players to throw at least two touchdowns in a matchup in 2025.
- Just one player has thrown for three or more TDs in an outing against the Bills this season.
- The 169.5 passing yards per game yielded by the Bills defense makes them the NFL's second-ranked pass defense.
- The Bills' defense is ranked seventh in the NFL with 16 passing TDs conceded so far this season.
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Sanders Passing Insights
- Sanders has bettered his passing yards prop total in three games this year, or 75.0%.
- The Browns have passed 58.6% of the time and run 41.4% this season. They rank 29th in the NFL in scoring.
- Sanders has 946 yards on 138 attempts this season to average 6.9 yards per attempt.
- Sanders has thrown for a touchdown in three of five games this year, with more than one TD pass once.
- He has six total touchdowns this season (26.1% of his team's 23 offensive TDs).
- Sanders has passed eight times out of his 138 total attempts while in the red zone (8.2% of his team's red zone plays).
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Sanders' Recent Performance
| Opponent | Date | Week | Passing Stats | Rushing Stats |
|---|---|---|---|---|
| vs. Bears | 12/14/2025 | Week 15 | 18-for-35 / 177 YDS / 0 TDs / 3 INTs | 2 ATT / 24 YDS / 0 TDs |
| vs. Titans | 12/7/2025 | Week 14 | 23-for-42 / 364 YDS / 3 TDs / 1 INT | 3 ATT / 29 YDS / 1 TD |
| vs. 49ers | 11/30/2025 | Week 13 | 16-for-25 / 149 YDS / 1 TD / 0 INTs | 1 ATT / 6 YDS / 0 TDs |
| vs. Raiders | 11/23/2025 | Week 12 | 11-for-20 / 209 YDS / 1 TD / 1 INT | 1 ATT / -1 YDS / 0 TDs |
| vs. Ravens | 11/16/2025 | Week 11 | 4-for-16 / 47 YDS / 0 TDs / 1 INT | 3 ATT / 16 YDS / 0 TDs |